High-performance epistasis detection in quantitative trait GWAS
نویسندگان
چکیده
منابع مشابه
FastEpistasis: a high performance computing solution for quantitative trait epistasis
MOTIVATION Genome-wide association studies have become widely used tools to study effects of genetic variants on complex diseases. While it is of great interest to extend existing analysis methods by considering interaction effects between pairs of loci, the large number of possible tests presents a significant computational challenge. The number of computations is further multiplied in the stu...
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Modeling and detecting nonallelic (epistatic) effects at multiple quantitative trait loci (QTL) often assume that the study population is in zygotic equilibrium (i.e., genotypic frequencies at different loci are products of corresponding single-locus genotypic frequencies). However, zygotic associations can arise from physical linkages between different loci or from many evolutionary and demogr...
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ژورنال
عنوان ژورنال: The International Journal of High Performance Computing Applications
سال: 2016
ISSN: 1094-3420,1741-2846
DOI: 10.1177/1094342016658110